SrasV1, Main, Exploration, bibRecord, 005B39

Evidence of airborne transmission of the severe acute respiratory syndrome virus

Identifieur interne : 005B39 ( Main/Exploration ); précédent : 005B38; suivant : 005B40

Evidence of airborne transmission of the severe acute respiratory syndrome virus

Auteurs : Ignatius T. S. Yu [Hong Kong] ; YUGUO LI [Hong Kong] ; TZE WAI WONG [Hong Kong] ; Wilson Tam [Hong Kong] ; Andy T. Chan [Hong Kong] ; Joseph H. W. Lee [Hong Kong] ; Dennis Y. C. Leung [Hong Kong] ; Tommy Ho [Hong Kong]

Source :

The New England journal of medicine [ 0028-4793 ] ; 2004.

RBID : Pascal:04-0224731

Descripteurs français

Pascal (Inist)
- Milieu aérien, Transmission, Virus, Médecine, Syndrome respiratoire aigu sévère.
Wicri :
- topic : Médecine.

English descriptors

KwdEn :
- Air environment, Medicine, Severe acute respiratory syndrome, Transmission, Virus.

Abstract

BACKGROUND There is uncertainty about the mode oftransmission ofthe severe acute respiratory syndrome (SARS) virus. We analyzed the temporal and spatial distributions of cases in a large community outbreak of SARS in Hong Kong and examined the correlation of these data with the three-dimensional spread of a virus-laden aerosol plume that was modeled using studies of airflow dynamics. METHODS We determined the distribution of the initial 187 cases of SARS in the Amoy Gardens housing complex in 2003 according to the date of onset and location of residence. We then studied the association between the location (building, floor, and direction the apartment unit faced) and the probability of infection using logistic regression. The spread ofthe airborne, virus-laden aerosols generated by the index patient was modeled with the use of airflow-dynamics studies, including studies performed with the use of computational fluid-dynamics and multizone modeling. RESULTS The curves of the epidemic suggested a common source of the outbreak. All but 5 patients lived in seven buildings (A to G), and the index patient and more than half the other patients with SARS (99 patients) lived in building E. Residents ofthe floors at the middle and upper levels in building E were at a significantly higher risk than residents on lower floors; this finding is consistent with a rising plume of contaminated warm air in the air shaft generated from a middle-level apartment unit. The risks for the different units matched the virus concentrations predicted with the use of multizone modeling. The distribution ofrisk in buildings B, C, and D corresponded well with the three-dimensional spread of virus-laden aerosols predicted with the use of computational fluid-dynamics modeling. CONCLUSIONS Airborne spread ofthe virus appears to explain this large community outbreak of SARS, and future efforts at prevention and control must take into consideration the potential for airborne spread ofthis virus.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">BACKGROUND There is uncertainty about the mode oftransmission ofthe severe acute respiratory syndrome (SARS) virus. We analyzed the temporal and spatial distributions of cases in a large community outbreak of SARS in Hong Kong and examined the correlation of these data with the three-dimensional spread of a virus-laden aerosol plume that was modeled using studies of airflow dynamics. METHODS We determined the distribution of the initial 187 cases of SARS in the Amoy Gardens housing complex in 2003 according to the date of onset and location of residence. We then studied the association between the location (building, floor, and direction the apartment unit faced) and the probability of infection using logistic regression. The spread ofthe airborne, virus-laden aerosols generated by the index patient was modeled with the use of airflow-dynamics studies, including studies performed with the use of computational fluid-dynamics and multizone modeling. RESULTS The curves of the epidemic suggested a common source of the outbreak. All but 5 patients lived in seven buildings (A to G), and the index patient and more than half the other patients with SARS (99 patients) lived in building E. Residents ofthe floors at the middle and upper levels in building E were at a significantly higher risk than residents on lower floors; this finding is consistent with a rising plume of contaminated warm air in the air shaft generated from a middle-level apartment unit. The risks for the different units matched the virus concentrations predicted with the use of multizone modeling. The distribution ofrisk in buildings B, C, and D corresponded well with the three-dimensional spread of virus-laden aerosols predicted with the use of computational fluid-dynamics modeling. CONCLUSIONS Airborne spread ofthe virus appears to explain this large community outbreak of SARS, and future efforts at prevention and control must take into consideration the potential for airborne spread ofthis virus.</div>
</front>
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<affiliations><list><country><li>Hong Kong</li>
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<name sortKey="Chan, Andy T" sort="Chan, Andy T" uniqKey="Chan A" first="Andy T." last="Chan">Andy T. Chan</name>
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<name sortKey="Lee, Joseph H W" sort="Lee, Joseph H W" uniqKey="Lee J" first="Joseph H. W." last="Lee">Joseph H. W. Lee</name>
<name sortKey="Leung, Dennis Y C" sort="Leung, Dennis Y C" uniqKey="Leung D" first="Dennis Y. C." last="Leung">Dennis Y. C. Leung</name>
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<name sortKey="Yuguo Li" sort="Yuguo Li" uniqKey="Yuguo Li" last="Yuguo Li">YUGUO LI</name>
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Evidence of airborne transmission of the severe acute respiratory syndrome virus

Evidence of airborne transmission of the severe acute respiratory syndrome virus

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri